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Ganesan Kamatchi

Dr. Ganesan L. Kamatchi
Professor of Biology
Office: WSB 300D
Lab: WSB 300
Office Phone: (757) 823-2327
Email: glkamatchi@nsu.edu
 

Brief Biography

Dr. Kamatchi is a professor of Biology at NSU since 2018.  He is a pharmacologist with extensive research background on voltage-gated calcium channels (VGCC).  Before joining NSU, Dr. Kamatchi was working at the University of Virginia at Charlottesville, VA and carried out research on the effects of volatile anesthetics on VGCCs (NIH grant, 2003-2008).  He joined NSU in 2009 and conducted research on the role of VGCCs on insulin release (NIH grant, 2012-2017).  He is also interested on the mechanism of food intake and the role of benzodiazepines on the feeding behavior.  Since he joined NSU, he has been teaching anatomy, physiology, zoology and cell biology courses.  He received NSUs summer grants several times and guided batches of students on electrophysiology.  He is an expert on gene expression and constantly expressing VGCCs in Xenopus laevis oocytes (African clawed frogs) and guides his students on this area of science.   

 

Detailed CV of Dr. Kamatchi

Research Interests

  • Ion channel physiology/pharmacology, with relevance to calcium and chloride channels.
  • Mechanism of protein kinase C-mediated phosphorylation.
  • Studying the mechanism of central nervous system acting drugs such as general anesthetics, sedative hypnotics and psychotherapeutic agents. 
  • Exploring the mechanism of action of central nervous system receptors, with particular emphasis on muscarinic and GABA receptors. 
  • Central nervous system regulation of food intake.

 

Selected Publications

  • Kamatchi, G.L., and Palaniswami Rathanaswami. Inhibition of Deprivation-induced Food Intake by GABAA Antagonists: Roles of the Hypothalamic, Endocrine and Alimentary Mechanisms. J Clin Biochem Nutr 51: 19-26; 2012.
  • Rajagopal, S., Fields, B.L., and Kamatchi, G.L. Contribution of Protein Kinase Ca in the Stimulation of Insulin by the Inhibition of Cavβ subunits. Endocrine 47: 463-471; 2014.
  • Rajagopal, S., Fields, B.L., Burton, B.K., On, C., Reeder, A.A., and Kamatchi, G.L. Inhibition of Protein Kinase C (PKC) Response of Voltage-gated Calcium (Cav) 2.2 Channels expressed in Xenopus oocytes by Cavβ subunits. Neuroscience 280: 1-9; 2014.
  • Rajagopal, S., Brittney K. Burton, Blanche L. Fields, India O. El and Kamatchi, G.L. Stimulatory and inhibitory effects of PKC isozymes are mediated by serine/threonine PKC sites of the Cav2.3α1 subunits. Arch Biochem Biophys 621: 24-30; 2017.