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Dr. Makarand Deo

Dr. Makarand Deo  Dr. Makarand Deo
  Associate Professor

  Office: RTC 410G
  Office Phone: (757) 823-8301
  FAX: (757) 823-2698

Computational Cardiac Engineering Lab

Brief Biography

Dr. Makarand Deo joined Norfolk State University in Fall 2012 as an Assistant Professor in the Department of Engineering. Dr. Deo has earned his PhD in Electrical Engineering from University of Calgary, Canada. His graduate and undergraduate degrees are from Indian Institute of Technology (IIT) Bombay and University of Pune, India, respectively. After PhD, Dr. Deo joined the reputed Center for Arrhythmia Research at the University of Michigan, Ann Arbor, MI, for his postdoctoral training followed by a research faculty position at the University of Toledo, OH.

Dr. Deo's research interests are in computational modeling of coupled systems and optics-based biosensing. He has developed anatomically and electrophysiologically realistic multiscale models of heart geometries derived from magnetic resonance imaging (MRI) scans in patients and animals. He has received several research-related awards including the American Heart Association's Scientist Development Grant (2012-2017), and Postdoctoral Fellowship (declined due to career transition). Currently Dr. Deo’s work has been supported by several research grants from National Science Foundation (NSF) and National Institutes of Health (NIH). Dr. Deo has a strong publication record in high-impact engineering as well as medical journals.

Detailed CV of Dr. Deo

Research Interests

  • Multiscale modeling and computer-aided simulations
  • Optics-based biosensing, light-tissue interaction
  • Machine learning/AI applications in bioengineering
  • Medical technology and sensor integration
  • Cardiac electrophysiology and arrhythmia mechanisms

Recent Publications

  • Berenfeld O, Filgueiras‐Rama D, Deo M. Rotors in Animal Models of Atrial Fibrillation. (Book Chapter) In: Cardiac Mapping, Fifth Edition, 2019 John Wiley & Sons Ltd. ISBN:978-111-915-259-0.
  • Shah C, Limbu B, Jiwani S, Weinberg SH, Deo M. Delayed Afterdepolarization-induced Triggered Activity in Cardiac Purkinje Cells Mediated through Cytosolic Calcium Diffusion Waves. Physiological Reports. 2019 Dec;7(24):e14296.
  • Limbu B, Shah K, Weinberg SH, Deo M. Role of Cytosolic Calcium Diffusion in Murine Cardiac Purkinje Cells. Clin Med Insights Cardiol. 2016 Jul 20;10(Suppl 1):17-26.
  • Willis BC, Pandit S, Ponce-Balbuena D, Zarzoso M, Guerrero-Serna G, Limbu B, Deo M, Cammors E, Ramirez RJ, Mironov S, Herron TJ, Valdivia HH, Jalife J. Constitutive Intracellular Na+ Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress than Ventricular Myocytes from Mice with Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. 2016 Jun 14;133(24):2348-59.
  • Ringenberg J, Deo M, Filgueiras-Rama D, Pizarro G, Ibañez B, Peinado R, Trayanova N, Miller M, Merino JL, Berenfeld O, Devabhaktuni V. Effects of fibrosis morphology on reentrant ventricular tachycardia inducibility and simulation fidelity in patient-derived models., Clin Med Insights Cardiol. 2014 Sep 25;8(Suppl 1):1-13.
  • Calvo CJ, Deo M, Zlochiver S, Millet J, Berenfeld O. Attraction of rotors to the pulmonary veins in paroxysmal atrial fibrillation: a modeling study. Biophys J. 2014 Apr 15;106(8):1811-21
  • Deo M, Ruan Y, Pandit SV, Shah K, Berenfeld O, Napolitano C, Jalife J, Priori S. Impaired inward rectification in a novel KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular pro-arrhythmia, Proceedings of the National Academy of Sciences of USA (PNAS). 2013; 110(11):4291-6.
  • Ringenberg J, Deo M, Devabhaktuni V, Filgueiras-Rama D, Pizzaro G, Berenfeld O, Boyers P, , Gold J. Automated segmentation and reconstruction of patient-specific cardiac anatomy and pathology from in vivo MRI. Measurement Science and Technology (Special Issue). 2012; 23(12): 125405:1-13.

(Updated 5/1/2020)